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Widespread remodeling of proteome solubility in response to different protein homeostasis stresses
The accumulation of protein deposits in neurodegenerative diseases has been hypothesized to depend on a metastable subproteome vulnerable to aggregation. To investigate this phenomenon and the mechanisms that regulate it, we measured the solubility of the proteome in the mouse Neuro2a cell line unde...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7007570/ https://ncbi.nlm.nih.gov/pubmed/31964829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912897117 |
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