Widespread remodeling of proteome solubility in response to different protein homeostasis stresses

The accumulation of protein deposits in neurodegenerative diseases has been hypothesized to depend on a metastable subproteome vulnerable to aggregation. To investigate this phenomenon and the mechanisms that regulate it, we measured the solubility of the proteome in the mouse Neuro2a cell line unde...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Sui, Xiaojing, Pires, Douglas E. V., Ormsby, Angelique R., Cox, Dezerae, Nie, Shuai, Vecchi, Giulia, Vendruscolo, Michele, Ascher, David B., Reid, Gavin E., Hatters, Danny M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007570/
https://ncbi.nlm.nih.gov/pubmed/31964829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912897117
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker