Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells

Mouse embryonic stem cells (ESCs) are isolated from the inner cell mass of blastocysts, and they exist in different states of pluripotency—naïve and primed states. Pten is a well-known tumor suppressor. Here, we generated Pten(−/−) mouse ESCs with the CRISPR-Cas9 system and verified that Pten(−/−) E...

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Udgivet i:Cell Death Dis
Main Authors: Wang, Wuming, Lu, Gang, Su, Xianwei, Tang, Chengcheng, Li, Hongjian, Xiong, Zhiqiang, Leung, Chi-Kwan, Wong, Man-Sze, Liu, Hongbin, Ma, Jin-Long, Cheung, Hoi-Hung, Kung, Hsiang-Fu, Chen, Zi-Jiang, Chan, Wai-Yee
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007436/
https://ncbi.nlm.nih.gov/pubmed/32034125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2271-0
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