Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors

p53-mutated tumors often exhibit increased resistance to standard chemotherapy and enhanced metastatic potential. Here we demonstrate that inhibition of dihydroorotate dehydrogenase (DHODH), a key enzyme of the de novo pyrimidine synthesis pathway, effectively decreases proliferation of cancer cells...

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Vydáno v:Cell Death Dis
Hlavní autoři: Hubackova, Sona, Davidova, Eliska, Boukalova, Stepana, Kovarova, Jaromira, Bajzikova, Martina, Coelho, Ana, Terp, Mikkel G., Ditzel, Henrik J., Rohlena, Jakub, Neuzil, Jiri
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007433/
https://ncbi.nlm.nih.gov/pubmed/32034120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2224-7
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