CUL3 deficiency causes social deficits and anxiety-like behaviors by impairing excitation-inhibition balance via promoting Cap-dependent translation

Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with symptoms including social deficits, anxiety, and communication difficulties. However, ASD pathogenic mechanisms are poorly understood. Mutations of CUL3, which encodes Cullin 3 (CUL3), a component of an E3 ligase comple...

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Udgivet i:Neuron
Main Authors: Dong, Zhaoqi, Chen, Wenbing, Chen, Chao, Wang, Hongsheng, Cui, Wanpeng, Tan, Zhibing, Robinson, Heath, Gao, Nannan, Luo, Bin, Zhang, Lei, Zhao, Kai, Xiong, Wen-Cheng, Mei, Lin
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007399/
https://ncbi.nlm.nih.gov/pubmed/31780330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.10.035
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