Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4

During aging, acetylcholine receptor (AChR) clusters become fragmented and denervated at the neuromuscular junction (NMJ). Underpinning molecular mechanisms are not well understood. We showed that LRP4, a receptor for agrin and critical for NMJ formation and maintenance, was reduced at protein level...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Zhao, Kai, Shen, Chengyong, Li, Lei, Wu, Haitao, Xing, Guanglin, Dong, Zhaoqi, Jing, Hongyang, Chen, Wenbing, Zhang, Hongsheng, Tan, Zhibing, Pan, Jinxiu, Xiong, Lei, Wang, Hongsheng, Cui, Wanpeng, Sun, Xiang-Dong, Li, Shihua, Huang, Xinping, Xiong, Wen-Cheng, Mei, Lin
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2018
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181315/
https://ncbi.nlm.nih.gov/pubmed/30171091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0860-18.2018
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