Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4

During aging, acetylcholine receptor (AChR) clusters become fragmented and denervated at the neuromuscular junction (NMJ). Underpinning molecular mechanisms are not well understood. We showed that LRP4, a receptor for agrin and critical for NMJ formation and maintenance, was reduced at protein level...

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Bibliografski detalji
Izdano u:J Neurosci
Glavni autori: Zhao, Kai, Shen, Chengyong, Li, Lei, Wu, Haitao, Xing, Guanglin, Dong, Zhaoqi, Jing, Hongyang, Chen, Wenbing, Zhang, Hongsheng, Tan, Zhibing, Pan, Jinxiu, Xiong, Lei, Wang, Hongsheng, Cui, Wanpeng, Sun, Xiang-Dong, Li, Shihua, Huang, Xinping, Xiong, Wen-Cheng, Mei, Lin
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2018
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181315/
https://ncbi.nlm.nih.gov/pubmed/30171091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0860-18.2018
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