Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4

During aging, acetylcholine receptor (AChR) clusters become fragmented and denervated at the neuromuscular junction (NMJ). Underpinning molecular mechanisms are not well understood. We showed that LRP4, a receptor for agrin and critical for NMJ formation and maintenance, was reduced at protein level...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Zhao, Kai, Shen, Chengyong, Li, Lei, Wu, Haitao, Xing, Guanglin, Dong, Zhaoqi, Jing, Hongyang, Chen, Wenbing, Zhang, Hongsheng, Tan, Zhibing, Pan, Jinxiu, Xiong, Lei, Wang, Hongsheng, Cui, Wanpeng, Sun, Xiang-Dong, Li, Shihua, Huang, Xinping, Xiong, Wen-Cheng, Mei, Lin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2018
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181315/
https://ncbi.nlm.nih.gov/pubmed/30171091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0860-18.2018
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