Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4

During aging, acetylcholine receptor (AChR) clusters become fragmented and denervated at the neuromuscular junction (NMJ). Underpinning molecular mechanisms are not well understood. We showed that LRP4, a receptor for agrin and critical for NMJ formation and maintenance, was reduced at protein level...

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Dades bibliogràfiques
Publicat a:J Neurosci
Autors principals: Zhao, Kai, Shen, Chengyong, Li, Lei, Wu, Haitao, Xing, Guanglin, Dong, Zhaoqi, Jing, Hongyang, Chen, Wenbing, Zhang, Hongsheng, Tan, Zhibing, Pan, Jinxiu, Xiong, Lei, Wang, Hongsheng, Cui, Wanpeng, Sun, Xiang-Dong, Li, Shihua, Huang, Xinping, Xiong, Wen-Cheng, Mei, Lin
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181315/
https://ncbi.nlm.nih.gov/pubmed/30171091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0860-18.2018
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