The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing α-synuclein

Ischemic stroke, caused by a clot that blocks blood flow to the brain, can be severely disabling and sometimes fatal. We previously showed that transient focal ischemia in a rat model induces extensive temporal changes in the cerebral miRNAome, with a sustained decrease in the abundance of miR-7a-5p...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Kim, TaeHee, Mehta, Suresh L, Morris-Blanco, Kahlilia C., Chokkalla, Anil K., Chelluboina, Bharath, Lopez, Mary, Sullivan, Ruth, Kim, Hung Tae, Cook, Thomas D., Kim, Joo Yong, Kim, HwuiWon, Kim, Chanul, Vemuganti, Raghu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005928/
https://ncbi.nlm.nih.gov/pubmed/30538177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aat4285
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