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Quantifying Hematopoietic Stem Cell Clonal Diversity by Selecting Informative Amplicon Barcodes

Hematopoietic stem cells (HSCs) are functionally and genetically diverse and this diversity decreases with age and disease. Numerous systems have been developed to quantify HSC diversity by genetic barcoding, but no framework has been established to empirically validate barcode sequences. Here we ha...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Teets, Emily M., Gregory, Charles, Shaffer, Jami, Blachly, James S., Blaser, Bradley W.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005852/
https://ncbi.nlm.nih.gov/pubmed/32034234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59119-8
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