Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses

The conserved hemagglutinin (HA) stem has been a focus of universal influenza vaccine efforts. Influenza A group 1 HA stem-nanoparticles have been demonstrated to confer heterosubtypic protection in animals; however, the protection does not extend to group 2 viruses, due in part to differences in gl...

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Publicado no:Nat Commun
Main Authors: Boyoglu-Barnum, Seyhan, Hutchinson, Geoffrey B., Boyington, Jeffrey C., Moin, Syed M., Gillespie, Rebecca A., Tsybovsky, Yaroslav, Stephens, Tyler, Vaile, John R., Lederhofer, Julia, Corbett, Kizzmekia S., Fisher, Brian E., Yassine, Hadi M., Andrews, Sarah F., Crank, Michelle C., McDermott, Adrian B., Mascola, John R., Graham, Barney S., Kanekiyo, Masaru
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005838/
https://ncbi.nlm.nih.gov/pubmed/32034141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14579-4
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