De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences

Recent evidence demonstrates that novel protein-coding genes can arise de novo from non-genic loci. This evolutionary innovation is thought to be facilitated by the pervasive translation of non-genic transcripts, which exposes a reservoir of variable polypeptides to natural selection. Here, we syste...

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發表在:Nat Commun
Main Authors: Vakirlis, Nikolaos, Acar, Omer, Hsu, Brian, Castilho Coelho, Nelson, Van Oss, S. Branden, Wacholder, Aaron, Medetgul-Ernar, Kate, Bowman, Ray W., Hines, Cameron P., Iannotta, John, Parikh, Saurin Bipin, McLysaght, Aoife, Camacho, Carlos J., O’Donnell, Allyson F., Ideker, Trey, Carvunis, Anne-Ruxandra
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005711/
https://ncbi.nlm.nih.gov/pubmed/32034123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14500-z
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