Dynamic (13)C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin

Cellular metabolism is dynamic, but quantifying non-steady metabolic fluxes by stable isotope tracers presents unique computational challenges. Here, we developed an efficient (13)C-tracer dynamic metabolic flux analysis (13C-DMFA) framework for modeling central carbon fluxes that vary over time. We...

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Gepubliceerd in:iScience
Hoofdauteurs: Quek, Lake-Ee, Krycer, James R., Ohno, Satoshi, Yugi, Katsuyuki, Fazakerley, Daniel J., Scalzo, Richard, Elkington, Sarah D., Dai, Ziwei, Hirayama, Akiyoshi, Ikeda, Satsuki, Shoji, Futaba, Suzuki, Kumi, Locasale, Jason W., Soga, Tomoyoshi, James, David E., Kuroda, Shinya
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005519/
https://ncbi.nlm.nih.gov/pubmed/32058966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100855
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