Dynamic (13)C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin

Cellular metabolism is dynamic, but quantifying non-steady metabolic fluxes by stable isotope tracers presents unique computational challenges. Here, we developed an efficient (13)C-tracer dynamic metabolic flux analysis (13C-DMFA) framework for modeling central carbon fluxes that vary over time. We...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Quek, Lake-Ee, Krycer, James R., Ohno, Satoshi, Yugi, Katsuyuki, Fazakerley, Daniel J., Scalzo, Richard, Elkington, Sarah D., Dai, Ziwei, Hirayama, Akiyoshi, Ikeda, Satsuki, Shoji, Futaba, Suzuki, Kumi, Locasale, Jason W., Soga, Tomoyoshi, James, David E., Kuroda, Shinya
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005519/
https://ncbi.nlm.nih.gov/pubmed/32058966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100855
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