Dynamic (13)C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin

Cellular metabolism is dynamic, but quantifying non-steady metabolic fluxes by stable isotope tracers presents unique computational challenges. Here, we developed an efficient (13)C-tracer dynamic metabolic flux analysis (13C-DMFA) framework for modeling central carbon fluxes that vary over time. We...

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Pubblicato in:iScience
Autori principali: Quek, Lake-Ee, Krycer, James R., Ohno, Satoshi, Yugi, Katsuyuki, Fazakerley, Daniel J., Scalzo, Richard, Elkington, Sarah D., Dai, Ziwei, Hirayama, Akiyoshi, Ikeda, Satsuki, Shoji, Futaba, Suzuki, Kumi, Locasale, Jason W., Soga, Tomoyoshi, James, David E., Kuroda, Shinya
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005519/
https://ncbi.nlm.nih.gov/pubmed/32058966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100855
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