Suprachoroidal and Subretinal Injections of AAV Using Transscleral Microneedles for Retinal Gene Delivery in Nonhuman Primates

Retinal gene therapy using adeno-associated viruses (AAVs) is constrained by the mode of viral vector delivery. Intravitreal AAV injections are impeded by the internal limiting membrane barrier, while subretinal injections require invasive surgery and produce a limited region of therapeutic effect....

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Bibliografiska uppgifter
I publikationen:Mol Ther Methods Clin Dev
Huvudupphovsmän: Yiu, Glenn, Chung, Sook Hyun, Mollhoff, Iris N., Nguyen, Uyen Tu, Thomasy, Sara M., Yoo, Jesse, Taraborelli, Donna, Noronha, Glenn
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Gene & Cell Therapy 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005511/
https://ncbi.nlm.nih.gov/pubmed/32055646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.01.002
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