Suprachoroidal and Subretinal Injections of AAV Using Transscleral Microneedles for Retinal Gene Delivery in Nonhuman Primates

Retinal gene therapy using adeno-associated viruses (AAVs) is constrained by the mode of viral vector delivery. Intravitreal AAV injections are impeded by the internal limiting membrane barrier, while subretinal injections require invasive surgery and produce a limited region of therapeutic effect....

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發表在:Mol Ther Methods Clin Dev
Main Authors: Yiu, Glenn, Chung, Sook Hyun, Mollhoff, Iris N., Nguyen, Uyen Tu, Thomasy, Sara M., Yoo, Jesse, Taraborelli, Donna, Noronha, Glenn
格式: Artigo
語言:Inglês
出版: American Society of Gene & Cell Therapy 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005511/
https://ncbi.nlm.nih.gov/pubmed/32055646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.01.002
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