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Suprachoroidal and Subretinal Injections of AAV Using Transscleral Microneedles for Retinal Gene Delivery in Nonhuman Primates
Retinal gene therapy using adeno-associated viruses (AAVs) is constrained by the mode of viral vector delivery. Intravitreal AAV injections are impeded by the internal limiting membrane barrier, while subretinal injections require invasive surgery and produce a limited region of therapeutic effect....
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| 發表在: | Mol Ther Methods Clin Dev |
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| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society of Gene & Cell Therapy
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7005511/ https://ncbi.nlm.nih.gov/pubmed/32055646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.01.002 |
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