Pluripotent stem cell–derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity

Antibody-dependent cellular cytotoxicity (ADCC) is a key effector mechanism of natural killer (NK) cells that is mediated by therapeutic monoclonal antibodies (mAbs). This process is facilitated by the Fc receptor CD16a on human NK cells. CD16a appears to be the only activating receptor on NK cells...

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Bibliografski detalji
Izdano u:Blood
Glavni autori: Zhu, Huang, Blum, Robert H., Bjordahl, Ryan, Gaidarova, Svetlana, Rogers, Paul, Lee, Tom Tong, Abujarour, Ramzey, Bonello, Gregory B., Wu, Jianming, Tsai, Pei-Fang, Miller, Jeffrey S., Walcheck, Bruce, Valamehr, Bahram, Kaufman, Dan S.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2020
Teme:
Hematopoiesis and Stem Cells
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005364/
https://ncbi.nlm.nih.gov/pubmed/31856277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000621
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