Pluripotent stem cell–derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity

Antibody-dependent cellular cytotoxicity (ADCC) is a key effector mechanism of natural killer (NK) cells that is mediated by therapeutic monoclonal antibodies (mAbs). This process is facilitated by the Fc receptor CD16a on human NK cells. CD16a appears to be the only activating receptor on NK cells...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Zhu, Huang, Blum, Robert H., Bjordahl, Ryan, Gaidarova, Svetlana, Rogers, Paul, Lee, Tom Tong, Abujarour, Ramzey, Bonello, Gregory B., Wu, Jianming, Tsai, Pei-Fang, Miller, Jeffrey S., Walcheck, Bruce, Valamehr, Bahram, Kaufman, Dan S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005364/
https://ncbi.nlm.nih.gov/pubmed/31856277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000621
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