Pluripotent stem cell–derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity

Antibody-dependent cellular cytotoxicity (ADCC) is a key effector mechanism of natural killer (NK) cells that is mediated by therapeutic monoclonal antibodies (mAbs). This process is facilitated by the Fc receptor CD16a on human NK cells. CD16a appears to be the only activating receptor on NK cells...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Zhu, Huang, Blum, Robert H., Bjordahl, Ryan, Gaidarova, Svetlana, Rogers, Paul, Lee, Tom Tong, Abujarour, Ramzey, Bonello, Gregory B., Wu, Jianming, Tsai, Pei-Fang, Miller, Jeffrey S., Walcheck, Bruce, Valamehr, Bahram, Kaufman, Dan S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
Soggetti:
Hematopoiesis and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005364/
https://ncbi.nlm.nih.gov/pubmed/31856277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000621
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