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Nucleotide inhibition of the pancreatic ATP-sensitive K(+) channel explored with patch-clamp fluorometry
Pancreatic ATP-sensitive K(+) channels (K(ATP)) comprise four inward rectifier subunits (Kir6.2), each associated with a sulphonylurea receptor (SUR1). ATP/ADP binding to Kir6.2 shuts K(ATP). Mg-nucleotide binding to SUR1 stimulates K(ATP). In the absence of Mg(2+), SUR1 increases the apparent affin...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7004565/ https://ncbi.nlm.nih.gov/pubmed/31909710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52775 |
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