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The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination
Mutations in the BRCA1 and BRCA2 genes predispose afflicted individuals to breast, ovarian, and other cancers. The BRCA-encoded products form complexes with other tumor suppressor proteins and with the recombinase enzyme RAD51 to mediate chromosome damage repair by homologous recombination, and also...
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| Veröffentlicht in: | Annu Rev Biochem |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7004434/ https://ncbi.nlm.nih.gov/pubmed/30917004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biochem-013118-111058 |
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