Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast

The nuclear farnesoid X receptor (FXR) and the enzyme soluble epoxide hydrolase (sEH) are validated molecular targets to treat metabolic disorders such as non‐alcoholic steatohepatitis (NASH). Their simultaneous modulation in vivo has demonstrated a triad of anti‐NASH effects and thus may generate s...

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Dettagli Bibliografici
Pubblicato in:ChemMedChem
Autori principali: Schierle, Simone, Helmstädter, Moritz, Schmidt, Jurema, Hartmann, Markus, Horz, Maximiliane, Kaiser, Astrid, Weizel, Lilia, Heitel, Pascal, Proschak, Anna, Hernandez‐Olmos, Victor, Proschak, Ewgenij, Merk, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
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Full Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004070/
https://ncbi.nlm.nih.gov/pubmed/31670489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900576
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