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Mutagenic Effects of a 2-Deoxyribonolactone -Thymine Glycol Tandem DNA Lesion in Human Cells

Tandem DNA lesions, containing two contiguously damaged nucleotides, are commonly formed by ionizing radiation. Their effects on replication in mammalian cells are largely unknown. Replication of isolated 2-deoxyribonolactone (L) and thymine glycol (Tg), and the tandem lesion 5’-LTg was examined in...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Naldiga, Spandana, Huang, Haidong, Greenberg, Marc M., Basu, Ashis K.
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003646/
https://ncbi.nlm.nih.gov/pubmed/31860280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b01058
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