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Mutagenic Effects of a 2-Deoxyribonolactone -Thymine Glycol Tandem DNA Lesion in Human Cells

Tandem DNA lesions, containing two contiguously damaged nucleotides, are commonly formed by ionizing radiation. Their effects on replication in mammalian cells are largely unknown. Replication of isolated 2-deoxyribonolactone (L) and thymine glycol (Tg), and the tandem lesion 5’-LTg was examined in...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Naldiga, Spandana, Huang, Haidong, Greenberg, Marc M., Basu, Ashis K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003646/
https://ncbi.nlm.nih.gov/pubmed/31860280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b01058
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