Loss of Histone H3 K79 Methyltransferase Dot1l Facilitates Kidney Fibrosis by Upregulating Endothelin 1 through Histone Deacetylase 2

BACKGROUND: The progression rate of CKD varies substantially among patients. The genetic and epigenetic contributions that modify how individual patients respond to kidney injury are largely unknown. Emerging evidence has suggested that histone H3 K79 methyltransferase Dot1l has an antifibrotic effe...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Zhang, Long, Chen, Lihe, Gao, Chao, Chen, Enuo, Lightle, Andrea R., Foulke, Llewellyn, Zhao, Bihong, Higgins, Paul J., Zhang, Wenzheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2020
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003297/
https://ncbi.nlm.nih.gov/pubmed/31843983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019070739
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