Suboptimal T-cell Therapy Drives a Tumor Cell Mutator Phenotype That Promotes Escape from Frontline Treatment

Antitumor T-cell responses raised by frontline therapies such as chemotherapy, radiation, tumor cell vaccines, and viroimmunotherapy tend to be weak, both quantitatively (low frequency) and qualitatively (low affinity). We show here that T cells that recognize tumor-associated antigens (TAAs) can di...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Evgin, Laura, Huff, Amanda L., Kottke, Timothy, Thompson, Jill, Molan, Amy M., Driscoll, Christopher B, Schuelke, Matthew, Shim, Kevin G, Wongthida, Phonphimon, Ilett, Elizabeth J., Smith, Karen Kaluza, Harris, Reuben S, Coffey, Matt, Pulido, Jose S, Pandha, Hardev, Selby, Peter J., Harrington, Kevin J, Melcher, Alan, Vile, Richard G
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003288/
https://ncbi.nlm.nih.gov/pubmed/30940643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0013
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