APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy

APOBEC3B, an anti-viral cytidine deaminase which induces DNA mutations, has been implicated as a mediator of cancer evolution and therapeutic resistance. Mutational plasticity also drives generation of neoepitopes, which prime anti-tumor T cells. Here, we show that overexpression of APOBEC3B in tumo...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Driscoll, Christopher B., Schuelke, Matthew R., Kottke, Timothy, Thompson, Jill M., Wongthida, Phonphimon, Tonne, Jason M., Huff, Amanda L., Miller, Amber, Shim, Kevin G., Molan, Amy, Wetmore, Cynthia, Selby, Peter, Samson, Adel, Harrington, Kevin, Pandha, Hardev, Melcher, Alan, Pulido, Jose S., Harris, Reuben, Evgin, Laura, Vile, Richard G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005822/
https://ncbi.nlm.nih.gov/pubmed/32034147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14568-7
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