Genetic disruption of KCC cotransporters in a mouse model of thalassemia intermedia.

β-thalassemia [β-Thal] is caused by defective β-globin production leading to globin chain imbalance, aggregation of free alpha chain in developing erythroblasts, reticulocytes, and mature circulating red blood cells. The hypochromic thalassemic red cells exhibit increased cell dehydration in associa...

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Publié dans:Blood Cells Mol Dis
Auteurs principaux: Shmukler, Boris E., Rivera, Alicia, Bhargava, Parul, Nishimura, Katherine, Kim, Edward H., Hsu, Ann, Wohlgemuth, Jay G., Morton, James, Snyder, L. Michael, De Franceschi, Lucia, Rust, Marco B., Hubner, Christian A., Brugnara, Carlo, Alper, Seth L.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002294/
https://ncbi.nlm.nih.gov/pubmed/31835175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2019.102389
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