Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation

Makorins are evolutionary conserved proteins that contain C(3)H-type zinc finger modules and a RING E3 ubiquitin ligase domain. In Drosophila, maternal Makorin 1 (Mkrn1) has been linked to embryonic patterning but the mechanism remained unsolved. Here, we show that Mkrn1 is essential for axis specif...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Dold, Annabelle, Han, Hong, Liu, Niankun, Hildebrandt, Andrea, Brüggemann, Mirko, Rücklé, Cornelia, Hänel, Heike, Busch, Anke, Beli, Petra, Zarnack, Kathi, König, Julian, Roignant, Jean-Yves, Lasko, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001992/
https://ncbi.nlm.nih.gov/pubmed/31978041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008581
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