Overexpression of p-Akt, p-mTOR and p-eIF4E proteins associates with metastasis and unfavorable prognosis in non-small cell lung cancer

The Akt (protein kinase B)/mammalian target of rapamycin (mTOR) pathway, which is dysregulated in various cancers, controls the assembly of eukaryotic translation initiation factor 4F (eIF4E) complex. However, whether aberrant expression of phosphorylated Akt (p-Akt), phosphorylated mTOR (p-mTOR) an...

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Опубликовано в: :PLoS One
Главные авторы: Lu, Junmi, Zang, Hongjing, Zheng, Hongmei, Zhan, Yuting, Yang, Yang, Zhang, Yuting, Liu, Sile, Feng, Juan, Wen, Qiuyuan, Long, Mengping, Fan, Songqing
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2020
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001968/
https://ncbi.nlm.nih.gov/pubmed/32023262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227768
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