CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway

The mammalian target of rapamycin (mTOR) is a potentially important therapeutic target in a broad range of cancer types. mTOR inhibitors such as rapamycin and its analogs (rapalogs) have been proven effective as anticancer agents in non-small cell lung cancer (NSCLC), whereas they strongly enhance p...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Wen, Qiuyuan, Wang, Weiyuan, Luo, Jiadi, Chu, Shuzhou, Chen, Lingjiao, Xu, Lina, Zang, Hongjing, Alnemah, Mohannad Ma, Ma, Jian, Fan, Songqing
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053688/
https://ncbi.nlm.nih.gov/pubmed/27050281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8497
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