Overexpression of p-Akt, p-mTOR and p-eIF4E proteins associates with metastasis and unfavorable prognosis in non-small cell lung cancer

The Akt (protein kinase B)/mammalian target of rapamycin (mTOR) pathway, which is dysregulated in various cancers, controls the assembly of eukaryotic translation initiation factor 4F (eIF4E) complex. However, whether aberrant expression of phosphorylated Akt (p-Akt), phosphorylated mTOR (p-mTOR) an...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lu, Junmi, Zang, Hongjing, Zheng, Hongmei, Zhan, Yuting, Yang, Yang, Zhang, Yuting, Liu, Sile, Feng, Juan, Wen, Qiuyuan, Long, Mengping, Fan, Songqing
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001968/
https://ncbi.nlm.nih.gov/pubmed/32023262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227768
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