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Protective effects of BACE1 inhibitory ligand molecules against amyloid beta-induced synaptic and mitochondrial toxicities in Alzheimer’s disease
Amyloid-β (Aβ) peptides are the major drivers of Alzheimer’s disease (AD) pathogenesis, and are formed by successive cleavage of the amyloid precursor protein (APP) by the beta and gamma secretases. Mounting evidence suggests that Aβ and mitochondrial structural and functional abnormalities are crit...
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| Publicado no: | Hum Mol Genet |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7001603/ https://ncbi.nlm.nih.gov/pubmed/31595293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz227 |
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