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Protective effects of BACE1 inhibitory ligand molecules against amyloid beta-induced synaptic and mitochondrial toxicities in Alzheimer’s disease
Amyloid-β (Aβ) peptides are the major drivers of Alzheimer’s disease (AD) pathogenesis, and are formed by successive cleavage of the amyloid precursor protein (APP) by the beta and gamma secretases. Mounting evidence suggests that Aβ and mitochondrial structural and functional abnormalities are crit...
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| Pubblicato in: | Hum Mol Genet |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7001603/ https://ncbi.nlm.nih.gov/pubmed/31595293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz227 |
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