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Protective effects of BACE1 inhibitory ligand molecules against amyloid beta-induced synaptic and mitochondrial toxicities in Alzheimer’s disease

Amyloid-β (Aβ) peptides are the major drivers of Alzheimer’s disease (AD) pathogenesis, and are formed by successive cleavage of the amyloid precursor protein (APP) by the beta and gamma secretases. Mounting evidence suggests that Aβ and mitochondrial structural and functional abnormalities are crit...

詳細記述

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書誌詳細
出版年:Hum Mol Genet
主要な著者: Pradeepkiran, Jangampalli Adi, Reddy, Arubala P, Yin, Xiangling, Manczak, Maria, Reddy, P Hemachandra
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001603/
https://ncbi.nlm.nih.gov/pubmed/31595293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz227
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