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Protective effects of BACE1 inhibitory ligand molecules against amyloid beta-induced synaptic and mitochondrial toxicities in Alzheimer’s disease

Amyloid-β (Aβ) peptides are the major drivers of Alzheimer’s disease (AD) pathogenesis, and are formed by successive cleavage of the amyloid precursor protein (APP) by the beta and gamma secretases. Mounting evidence suggests that Aβ and mitochondrial structural and functional abnormalities are crit...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Pradeepkiran, Jangampalli Adi, Reddy, Arubala P, Yin, Xiangling, Manczak, Maria, Reddy, P Hemachandra
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001603/
https://ncbi.nlm.nih.gov/pubmed/31595293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz227
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