Flow cytometric micronucleus assay and TGx-DDI transcriptomic biomarker analysis of ten genotoxic and non-genotoxic chemicals in human HepaRG™ cells

BACKGROUND: Modern testing paradigms seek to apply human-relevant cell culture models and integrate data from multiple test systems to accurately inform potential hazards and modes of action for chemical toxicology. In genetic toxicology, the use of metabolically competent human hepatocyte cell cult...

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Detalhes bibliográficos
Publicado no:Genes Environ
Main Authors: Buick, Julie K., Williams, Andrew, Gagné, Rémi, Swartz, Carol D., Recio, Leslie, Ferguson, Stephen S., Yauk, Carole L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001283/
https://ncbi.nlm.nih.gov/pubmed/32042365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41021-019-0139-2
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