Flow cytometric micronucleus assay and TGx-DDI transcriptomic biomarker analysis of ten genotoxic and non-genotoxic chemicals in human HepaRG™ cells

BACKGROUND: Modern testing paradigms seek to apply human-relevant cell culture models and integrate data from multiple test systems to accurately inform potential hazards and modes of action for chemical toxicology. In genetic toxicology, the use of metabolically competent human hepatocyte cell cult...

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Bibliografiske detaljer
Udgivet i:Genes Environ
Main Authors: Buick, Julie K., Williams, Andrew, Gagné, Rémi, Swartz, Carol D., Recio, Leslie, Ferguson, Stephen S., Yauk, Carole L.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001283/
https://ncbi.nlm.nih.gov/pubmed/32042365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41021-019-0139-2
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