Flow cytometric micronucleus assay and TGx-DDI transcriptomic biomarker analysis of ten genotoxic and non-genotoxic chemicals in human HepaRG™ cells

BACKGROUND: Modern testing paradigms seek to apply human-relevant cell culture models and integrate data from multiple test systems to accurately inform potential hazards and modes of action for chemical toxicology. In genetic toxicology, the use of metabolically competent human hepatocyte cell cult...

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Vydáno v:Genes Environ
Hlavní autoři: Buick, Julie K., Williams, Andrew, Gagné, Rémi, Swartz, Carol D., Recio, Leslie, Ferguson, Stephen S., Yauk, Carole L.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001283/
https://ncbi.nlm.nih.gov/pubmed/32042365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41021-019-0139-2
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