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The Emerging Role of Cytidine Deaminase in Human Diseases: A New Opportunity for Therapy?

The recycling activity of cytidine deaminase (CDA) within the pyrimidine salvage pathway is essential to DNA and RNA synthesis. As such, CDA deficiency can lead to replicative stress, notably in Bloom syndrome. Alternatively, CDA also can deaminate cytidine and deoxycytidine analog-based therapies,...

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Publicat a:Mol Ther
Autors principals: Frances, Audrey, Cordelier, Pierre
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001087/
https://ncbi.nlm.nih.gov/pubmed/31870623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.11.026
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