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The Emerging Role of Cytidine Deaminase in Human Diseases: A New Opportunity for Therapy?
The recycling activity of cytidine deaminase (CDA) within the pyrimidine salvage pathway is essential to DNA and RNA synthesis. As such, CDA deficiency can lead to replicative stress, notably in Bloom syndrome. Alternatively, CDA also can deaminate cytidine and deoxycytidine analog-based therapies,...
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| Publicado no: | Mol Ther |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Gene & Cell Therapy
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7001087/ https://ncbi.nlm.nih.gov/pubmed/31870623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.11.026 |
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