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Retroviral Insertional Mutagenesis in Humans: Evidence for Four Genetic Mechanisms Promoting Expansion of Cell Clones

Integration of new DNA into a cellular chromosome can alter the activity of nearby genes, sometimes affecting subsequent cell growth. A potent form of insertional mutagenesis involves integration of retroviral DNA produced by reverse transcription, a required step in the replication of retroviruses....

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Библиографические подробности
Опубликовано в: :Mol Ther
Главный автор: Bushman, Frederic D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Gene & Cell Therapy 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001082/
https://ncbi.nlm.nih.gov/pubmed/31951833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.12.009
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