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Retroviral integration and human gene therapy

Long-term correction of genetic diseases requires permanent integration of therapeutic genes into chromosomes of affected cells. Retroviral vectors are the most widely used delivery vehicles because of their efficiency and precision of integration. However, retroviral integration can take place at a...

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Bibliographic Details
Main Author: Bushman, Frederic D.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934602/
https://ncbi.nlm.nih.gov/pubmed/17671645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32949
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