Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently of Oas1b

The explosive spread of Zika virus (ZIKV) has been associated with major variations in severe disease and congenital afflictions among infected populations, suggesting an influence of host genes. We investigated how genome-wide variants could impact susceptibility to ZIKV infection in mice. We first...

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Vydáno v:J Virol
Hlavní autoři: Manet, Caroline, Simon-Lorière, Etienne, Jouvion, Grégory, Hardy, David, Prot, Matthieu, Conquet, Laurine, Flamand, Marie, Panthier, Jean-Jacques, Sakuntabhai, Anavaj, Montagutelli, Xavier
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000970/
https://ncbi.nlm.nih.gov/pubmed/31694939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01034-19
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