Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently of Oas1b

The explosive spread of Zika virus (ZIKV) has been associated with major variations in severe disease and congenital afflictions among infected populations, suggesting an influence of host genes. We investigated how genome-wide variants could impact susceptibility to ZIKV infection in mice. We first...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Manet, Caroline, Simon-Lorière, Etienne, Jouvion, Grégory, Hardy, David, Prot, Matthieu, Conquet, Laurine, Flamand, Marie, Panthier, Jean-Jacques, Sakuntabhai, Anavaj, Montagutelli, Xavier
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2020
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000970/
https://ncbi.nlm.nih.gov/pubmed/31694939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01034-19
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