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A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation

IκB kinase 2 (IKK2) is well known for its pivotal role as a mediator of the canonical NF-κB pathway, which has important functions in inflammation and immunity, but also in cancer. Here we identify a novel and critical function of IKK2 and its co-factor NEMO in the activation of oncogenic c-Jun N-te...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Voigt, Stefanie, Sterz, Kai R., Giehler, Fabian, Mohr, Anne-Wiebe, Wilson, Joanna B., Moosmann, Andreas, Kieser, Arnd
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000802/
https://ncbi.nlm.nih.gov/pubmed/32019925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14502-x
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