A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus release

BACKGROUND: Tetherin (or BST-2) is an antiviral host restriction factor that suppresses the release of HIV-1 and other enveloped viruses by tethering them to the cell surface. Recently, it has been demonstrated that tetherin also acts as an innate sensor of HIV-1 assembly that induces NF-κB-dependen...

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Bibliografiske detaljer
Main Authors: Sauter, Daniel, Hotter, Dominik, Engelhart, Susanne, Giehler, Fabian, Kieser, Arnd, Kubisch, Christian, Kirchhoff, Frank
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751106/
https://ncbi.nlm.nih.gov/pubmed/23937976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-85
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