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A kinetic method for measuring agonist efficacy and ligand bias using high resolution biosensors and a kinetic data analysis framework
The kinetics/dynamics of signaling are of increasing value for G-protein-coupled receptor therapeutic development, including spatiotemporal signaling and the kinetic context of biased agonism. Effective application of signaling kinetics to developing new therapeutics requires reliable kinetic assays...
Kaydedildi:
| Yayımlandı: | Sci Rep |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group UK
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7000712/ https://ncbi.nlm.nih.gov/pubmed/32019973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58421-9 |
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