CCR2 enhances CD25 expression by FoxP3(+) regulatory T cells and regulates their abundance independently of chemotaxis and CCR2(+) myeloid cells

A wide array of chemokine receptors, including CCR2, are known to control Treg migration. Here, we report that CCR2 regulates Tregs beyond chemotaxis. We found that CCR2 deficiency reduced CD25 expression by FoxP3(+) Treg cells. Such a change was also consistently present in irradiation chimeras rec...

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Vydáno v:Cell Mol Immunol
Hlavní autoři: Zhan, Yifan, Wang, Nancy, Vasanthakumar, Ajithkumar, Zhang, Yuxia, Chopin, Michael, Nutt, Stephen L., Kallies, Axel, Lew, Andrew M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000403/
https://ncbi.nlm.nih.gov/pubmed/30538272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-018-0187-8
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