CCR2 enhances CD25 expression by FoxP3(+) regulatory T cells and regulates their abundance independently of chemotaxis and CCR2(+) myeloid cells

A wide array of chemokine receptors, including CCR2, are known to control Treg migration. Here, we report that CCR2 regulates Tregs beyond chemotaxis. We found that CCR2 deficiency reduced CD25 expression by FoxP3(+) Treg cells. Such a change was also consistently present in irradiation chimeras rec...

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Detalhes bibliográficos
Publicado no:Cell Mol Immunol
Main Authors: Zhan, Yifan, Wang, Nancy, Vasanthakumar, Ajithkumar, Zhang, Yuxia, Chopin, Michael, Nutt, Stephen L., Kallies, Axel, Lew, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000403/
https://ncbi.nlm.nih.gov/pubmed/30538272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-018-0187-8
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