Cdh1-mediated Skp2 degradation by dioscin reprogrammes aerobic glycolysis and inhibits colorectal cancer cells growth

BACKGROUND: The F-box protein S-phase kinase-associated protein 2 (Skp2) is overexpressed and correlated with poor prognosis in human malignancies, including colorectal cancer (CRC). METHODS: A natural product library was used for natural compound screening through glycolysis analysis. The expressio...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Zhou, Li, Yu, Xinfang, Li, Ming, Gong, Guanghui, Liu, Wenbin, Li, Tian, Zuo, Huilan, Li, Wei, Gao, Feng, Liu, Haidan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000337/
https://ncbi.nlm.nih.gov/pubmed/31806563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.11.031
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