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Combining Precursor and Fragment Information for Improved Detection of Differential Abundance in Data Independent Acquisition

In bottom-up, label-free discovery proteomics, biological samples are acquired in a data-dependent (DDA) or data-independent (DIA) manner, with peptide signals recorded in an intact (MS1) and fragmented (MS2) form. While DDA has only the MS1 space for quantification, DIA contains both MS1 and MS2 at...

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Bibliografische gegevens
Gepubliceerd in:Mol Cell Proteomics
Hoofdauteurs: Huang, Ting, Bruderer, Roland, Muntel, Jan, Xuan, Yue, Vitek, Olga, Reiter, Lukas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Biochemistry and Molecular Biology 2020
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000113/
https://ncbi.nlm.nih.gov/pubmed/31888964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA119.001705
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