Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease

Osteolytic lesions in multiple myeloma are caused by osteoclast-mediated bone resorption and reduced bone formation. A unique feature of myeloma is a failure of bone healing after successful treatment. We observed adipocytes on trabecular bone near the resorbed area in successfully treated patients....

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Liu, Huan, He, Jin, Koh, Su Pin, Zhong, Yuping, Liu, Zhiqiang, Wang, Zhiqiang, Zhang, Yujin, Li, Zongwei, Tam, Bjorn T., Lin, Pei, Xiao, Min, Young, Ken H., Amini, Behrang, Starbuck, Michael W., Lee, Hans C., Navone, Nora M., Davis, Richard E., Tong, Qiang, Bergsagel, P. Leif, Hou, Jian, Yi, Qing, Orlowski, Robert Z., Gagel, Robert F., Yang, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6999853/
https://ncbi.nlm.nih.gov/pubmed/31142679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aau9087
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