Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability

Shortening of mRNA poly(A) tails (deadenylation) to trigger their decay is mediated mainly by the CCR4-NOT deadenylase complex. While four catalytic subunits (CNOT6, 6L 7, and 8) have been identified in the mammalian CCR4-NOT complex, their individual biological roles are not fully understood. In th...

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Bibliographische Detailangaben
Veröffentlicht in:RNA Biol
Hauptverfasser: Mostafa, Dina, Takahashi, Akinori, Yanagiya, Akiko, Yamaguchi, Tomokazu, Abe, Takaya, Kureha, Taku, Kuba, Keiji, Kanegae, Yumi, Furuta, Yasuhide, Yamamoto, Tadashi, Suzuki, Toru
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6999631/
https://ncbi.nlm.nih.gov/pubmed/31924127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2019.1709747
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