WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death

Mutations in the macroautophagy/autophagy gene WDR45 cause β-propeller protein-associated neurodegeneration (BPAN); however the molecular and cellular mechanism of the disease process is largely unknown. Here we generated constitutive wdr45 knockout (KO) mice that displayed cognitive impairments, ab...

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書目詳細資料
發表在:Autophagy
Main Authors: Wan, Huida, Wang, Qi, Chen, Xiuting, Zeng, Qiufang, Shao, Yanjiao, Fang, Houqin, Liao, Xun, Li, Hu-Song, Liu, Ming-Gang, Xu, Tian-Le, Diao, Miaomiao, Li, Dali, Meng, Bo, Tang, Bin, Zhang, Zhuohua, Liao, Lujian
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2019
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6999610/
https://ncbi.nlm.nih.gov/pubmed/31204559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1630224
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